1329. Vancomycin Therapeutic Drug Monitoring: How to hit the Curve

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Therapeutic drug monitoring of vancomycin.

Vancomycin, a glycopeptide antibiotic, was developed-and released in the 1950's for the treatment of aerobic gram-positive infections and has been widely used mainly in the treatment of methicillin-resistant Staphylococcus aureus infections. Early reports regarding the possibility of nephrotoxicity and ototoxicity led to concern about the use of vancomycin and the need to monitor serum concentr...

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A review of vancomycin therapeutic drug monitoring recommendations in Scotland.

NephSAP 2007; 6: 199–280. 6. Halperin ML, Kamel KS. Potassium. Lancet 1998; 352: 135–40. 7. Grimm PR, Sansom SC. BK channels in the kidney. Curr Opin Nephrol Hypertens 2007; 16: 430–6. 8. Oster JR, Singer I, Thatte L et al. The polyuria of solute diuresis. Arch Intern Med 1997; 157: 721–9. 9. Mittal VK, Pierce AK, Priestley JC. Use of probenecid in ticarcillin-induced hypokalemia. Clin Ther 198...

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Clinical efficacy of therapeutic drug monitoring in patients receiving vancomycin.

Efficacy of therapeutic drug monitoring (TDM) of vancomycin (VCM) was retrospectively investigated in 184 patients with methicillin-resistant Staphylococcus aureus (MRSA) infection. The incidence of nephrotoxicity was compared between the patients who received TDM practice (TDM group, n=73) and did not (non-TDM group, n=111). Creatinine clearance (CLcr) values decreased significantly after the ...

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Guidelines for Therapeutic Drug Monitoring of Vancomycin: A Systematic Review

BACKGROUND AND OBJECTIVE Despite the availability of clinical practice guidelines (CPGs) for therapeutic drug monitoring (TDM) of vancomycin, vancomycin serum concentrations still do not reach therapeutic concentrations in many patients. Thus, we sought to systematically review the quality and consistency of recommendations for an international cohort of CPGs regarding vancomycin TDM. METHODS...

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ژورنال

عنوان ژورنال: Open Forum Infectious Diseases

سال: 2020

ISSN: 2328-8957

DOI: 10.1093/ofid/ofaa439.1511